Independent Research
43. Total Synthesis, Biological Evaluation and Biosynthetic Re-Evaluation of Illicium-Derived Neolignans
Robert; Saska, Jan; Mesquita-Ribeiro, Raquel; Dajas-Bailador, Federico; Lewis, William; Taylor, Laurence; Argent, Stephen; Shao, Huiling; Houk, K.; Denton, Ross
2024, Submitted
42. Synthesis, Structure and Stereodynamics of Atropisomeric N-Chloroamides
Aaron D. G. Campbell, Natalie J. Roper, Paul G. Waddell, Corinne Wills, Casey M. Dixon, Ross M. Denton, Kristaps Ermanis, Roly J. Armstrong, Chem. Commun. 2024, accepted.
41. Modular Synthesis of Cyclic β-Difluoroamines (with AstraZeneca) under revision 2024 View Preprint: https://chemrxiv.org/engage/chemrxiv/article-details/65c9d784e9ebbb4db9283d2c
40. Silyl Esters as Reactive Intermediates in Organic Synthesis
D’Amaral, M.C.; Andrews, K.G.; Denton, R.M.; Adler, M.J. Synth. 2023, DOI: 10.1055/a-2083-8591.
39. Modular synthesis of α,α-diaryl α-amino esters via Bi(V)-mediated arylation/SN2-displacement of Kukhtin–Ramirez intermediates
Calcatelli, A.; Denton, R. M.; Ball, L. T. Org. Lett. 2022, 24, 8002.
38. In Situ Silane Activation Enables Catalytic Reduction of Carboxylic Acids (with GSK)
Stoll. E.L., Barber, T.; Hirst, D.J.; Denton, R.M. Chem. Commun. 2022, 58, 3509.
37. A Practical Catalytic Reductive Amination of Carboxylic Acids (with GSK)
Stoll, E.L.; Tongue, T.; Andrews, K.G.; Hirst, D.G.; Valette, D.; Denton, R.M., Chem. Sci., 2020, 11, 9494.
36. Synthesis of 18O-labelled alcohols from unlabelled alcohols (with GSK)
Beddoe, R.H.; Edwards, D.C.; Goodman, L.; Sneddon, H.F.; Denton, R.M. Chem. Commun., 2020, 56, 6480. Front cover.
35. Development of a more sustainable Appel reaction (with GSK)
Jordan, A.*; Sneddon, H.F.; Denton, R.M. ACS Sustainable Chem. Eng. 2020, 8, 5
34. Redox Neutral Organocatalytic Mitsunobu Reactions (with GSK)
Beddoe, R.H.; Andrews, K.G.; Magne, V.; Cuthbertson, J.D.; Saska, J.; Shannon-Little, A.L.; Shanahan, S.E.; Sneddon, H.F.; Denton, R.M. Science, 2019, 365, 910
33. The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the art (with GSK)
Beddoe, R.H.; Sneddon, H.F.; Denton, R.M. Org. Biomol. Chem. 2018, 16, 7774
32. A More Critical Role for Silicon in the Catalytic Staudinger Amidation: Silanes as Non-Innocent Reductants
Andrews, K.; Denton, R.M. Chem. Commun. 2017, 53, 7971. Front cover.
31. A Practical and Catalyst-Free Trifluoroethylation Reaction of Amines Using Trifluoroacetic Acid.
Andrews, K.; Faizova, R.; Denton, R.M. Nature Commun. 2017, 8, 15913.
30. Synthesis of Malhamensilipin A Exploiting Iterative Epoxidation/Chlorination: Experimental and Computational Analysis of Epoxide-Derived Chloronium Ions
Saska, J.; Lewis, W.; Paton, R.; Denton R.M. Chem. Sci. 2016, 7, 7040.
29. Synthesis of Quaternary Aryl Phosphonium Salts: Photoredox Initiated Phosphine Arylation
Fearnley, A.F.; An, J.; Jackson, M.; Lindovska, P.; Denton, R.M. Chem. Commun. 2016, 52, 4987.
28. Catalytic Reductive N-Alkylation of Amines using Carboxylic Acids
Andrews, K.; Summers, D.; Donnelly, L.; Denton, R.M. Chem. Commun. 2016, 52, 1855.
27. Development of a Redox-Free Mitsunobu Reaction Exploiting Phosphine Oxides as Precursors to Dioxyphosphoranes (with GSK)
Tang, X.; Chapman, C.; Whiting M.; Denton, R.M. Chem. Commun. 2014, 50, 7340.
26. The Development of Catalytic Nucleophilic Substitution Reactions: Challenges, Progress and Future Directions
Jie, A.; Denton, R.M.; Lambert T.L.; Nacsa, E. Org. Biomol. Chem. 2014, 12, 2993.
25. A Simple Method for Appel Reactions Using a Polystyrene Supported Phopshine Oxide
Tang, X.; An, J.; Denton, R.M. Tetrahedron Lett. 2014, 4, 799.
24. Heteroatom Methods (review article)
An, J.; Denton, R.M. Annu. Rep. Org. Chem., Sect. B: Org. Chem. 2013, 109, 167.
23. Phosphorus(V)-Catalysed Dichlorination Reactions of Aldehydes
An, J.; Tang, X.; Moore, J.; Lewis, W.; Denton, R.M. Tetrahedron 2013, 69, 8769.
22. A Strategy For The Synthesis Of The Fargenone/Fargenin Family of Natural Products: Synthesis Of The Tricyclic Core
R.M. Denton, J.S. Scragg, Org. Biomol. Chem 2012, 10, 5629
21. Phosphonium Salt-Catalysed Synthesis of Nitriles From In Situ Activated Oximes
Denton R.M.; An, J.; Lindovska, P.; Lewis, W. Tetrahedron, 2012, 68, 2899
20. Catalytic Phosphorus(V)-Mediated Nucleophilic Substitution Reactions: Development Of A Catalytic Appel Reaction
Denton, R.M.; An, J.; Adeniran, B.; Blake, A.; Lewis, W.; Poulton, A. J. Org. Chem. 2011, 76, 6749
Highlighted in ACS New and Noteworthy Chemistry. Highlighted in Functional Group Transformations on the Organic Chemistry Portal. Highlighted in Green Chemistry Articles of Interest to the Pharmaceutical Industry in Organic Process Research and Development. Highlighted in Sustainable Chemistry Challenges and Practices for the Chemical and Pharmacuetical Industry.
19. A Concise Synthesis of O-methyl Honokiol
Denton, R.M.; Scragg, J.T.; Saska, J. Tetrahedron Lett. 2011, 52, 2554
18. Catalysis of Phosphorus(V)-Mediated Transformations: Catalytic Dichlorination of Epoxides Under Appel Conditions
Denton, R.M.; Tang, X.; Przeslak, A. Org. Lett. 2010, 12, 4678
17. Phosphine Oxide-Catalysed Chlorination of Alcohols Under Appel Conditions
Denton, R.M.; An, J. ; Adeniran, B. Chem. Commun. 2010, 46, 3025
16. A Concise Synthesis Of Honokiol
Denton, R.M.; Scragg, J.T.; Galofre, A.M.; Gui, X.; Lewis, W. Tetrahedron 2010, 66, 8029
15. A Concise Synthesis Of Dunnianol
Denton, R.M.; Scragg, J.T. Synlett 2010, 633
Postdoctoral Research
14. Lesser-Known Enabling Technologies For Organic Synthesis
O’Brien, M.; Denton, R.M.; Ley, S.V. Synthesis 2010, 8, 1157
13. RAR Signalling Regulates Choroid Fissure Closure Through Independent Mechanisms In The Ventral Optic Cup and Periocular Mesenchym
Lupo, G.; Gestri, G.; O’Brien, M.; Denton, R.M. Chandraratna, R.A.S.; Ley, S.V.; Harris W.A.; Wilson, S.W. Proc. Nat. Acad. Sci. 2011, 108, 8698.
12. Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin
Nicolaou, K.C.; Frederick, M.O.; Burtuloso, A.; Denton, R.M.; Rivas, F.; Cole, K.P. R.; Aversa, R. Gibe, R.; Umezawa, T.; Suzuki, T. J. Am. Chem. Soc. 2008, 130, 7466–7476
11. Total Synthesis of Artochamins F, H, I and J Through Cascade Reactions
Nicolaou, K.C.; Lister, T.; Denton, R.M.; Gelin, C.F. Tetrahedron 2008, 64, 4736
10. Design, Synthesis and Biological Evaluation of Platensimycin Analogs with Varying Degrees of Molecular Complexity
Nicolaou, K.C.; Stepan, A.F.; Lister, T.; Li, A.; Montero, A.; Tria, G.S.; Turner, C.I.; Tang, Y.; Wang, J.; Denton, R.M.; Edmonds, D.J. J. Am. Chem. Soc. 2008, 130, 13110
9. The Synthesis of Azadirachtin: A Potent Insect Antifeedant
Ley, S.V.; Somovilla, A.A.; Anderson, J.C.; Ayats, C.; Bänteli, R.; Beckmann, R.E.; Boyer, A.; M. Brasca, M.G.; Brice, A.; Broughton, H.B.; Burke, B.J.; Cleator, E.; Craig, D.; Denholm, A.A.; Denton, R.M.; Reville, T.D.; Gobbi, L.B.; Göbel, M.; Gray, B.L.; Grossmann, R.B.; Gutteridge, C.E.; Hahn, N.; Harding, S.L.; Jennens, D.C.; Jennens, L.; Lovell, P.J.; Lovell, H.J.; de la Puente, M.L.; Kolb, H.C.; Koot, W.J.; Maslen, S.L.; McCusker, C.F.; Mattes, A.; Pape, A.R.; Pinto, A.; Santafianos, D.; Scott, J.S.; Smith, S.C.; Somers, A.Q.; Spilling, C.D.; Stelzer, F.; Toogood, P.L.; Turner, R.M.; Veitch, G.E.; Wood, A.; Zumbrunn, C. Chem. Eur. J. 200814, 10683-10704
8. Metathesis Reactions in the Synthesis of Complex Molecules
Nicolaou K.C.; Ortiz, A.; Denton, R.M. Chemica Oggi, 2007, 5, 70–72, 74–76
7. Cascade Reactions Involving Formal [2+2] Cycloadditions: Total Synthesis of Artochamins F,H,I,J
Nicolaou, K.C.; Lister, T.; Denton, R.M.; Gelin, C.F. Angew. Chem. Int. Ed. 2007, 39, 7501
6. Chemical Synthesis of the GHIJK Ring System and Experimental Support for the Originally Assigned Structure of Maitotoxin
Nicolaou, K.C.; Cole, K.P.; Frederick, M.O.; Aversa, R.J.; Denton, R.M. Angew. Chem. Int. Ed. 2007, 46, 8875–8879
5. Adamantaplatensimycin a Bioactive Analogue of Platensimycin
Nicolaou, K.C.; Lister, T.; Denton, R.M; Montero, A.; Edmonds, D.J Angew. Chem. Int. Ed. 2007, 46, 4712
4. Stereocontrolled Synthesis of Model Core Systems of Lomaiviticins A and B
Nicolaou, K.C.; Denton, R.M.; Lenzen, A.; Edmonds, D.J.; Li, A.; Milburn, R.; Harrison, S. Angew. Chem. Int. Ed. 2006, 118, 2130
Doctoral Research
3. Asymmetric Synthesis of 6’-hydroxyarenarol: The Proposed Biosynthetic Precursor to Popolohuanone E
Munday, R.H.; Denton, R.M.; Anderson, J.C. J. Org. Chem. 2008, 73, 8033
2. A Biomimetic Strategy for the Synthesis of the Tricyclic Aromatic Core of Popolohuanone E
Anderson, J.C.; Denton, R.M.; Wilson, C. Org. Lett. 2005,7, 123
1. Synthesis of Dibenzofuran-1,4-Diones Using the Dotz Benzannulation
Anderson, J.C., Denton, R.M.; Hicken, G.; Wilson, C. Tetrahedron 2004, 60, 2327
Book Chapters and Conference Abstracts
2. Modern NMR Spectroscopy
in Organic Chemist’s Desk Reference Denton, R.M., Ed. C. Cooper. 2010, CRC Press
1. Total Synthesis of Artochamins F,H,I and J
K.C. Nicolaou, C.F, Gelin, T. Lister, R.M. Denton, Abstracts, 41st Western Regional ACS meeting, San Diego, October 9-13, 2007
The Denton Chemistry Group 